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ALD/NAFLD Index is used for distinguishing Alcoholic from Nonalcoholic Fatty Liver Disease.

C-peptide to insulin molar ratio is helpful in detecting exogenous insulin use, impaired hepatic insulin clearance and impaired C-peptide clearance by the kidneys.

Estimates functional vitamin B12 status from two to four B12-related markers. The more markers available, the higher the precision.

The D/T ratio is used to differentiate between different types of jaundice and liver injury patterns.

Estimated glomerular filtration rate from serum creatinine using the race-free CKD-EPI 2021 equation. Affected by muscle mass, meat or creatine intake, exercise, sarcopenia, and immobility.

Combined creatinine and cystatin C estimate of glomerular filtration correlates best with the measured GFR.

Estimated glomerular filtration rate from cystatin C. Independent of muscle mass. Affected by thyroid function, chronic inflammation, corticosteroids, and obesity.

eGFRdiff is calculated by subtracting creatinine eGFR (eGFRcr) from cystatin C eGFR (eGFRcys). It helps show whether the two kidney estimates agree and, if they do not, what the disagreement may mean.

The Fibrosis-3 Index is an improved version of the FIB-4, that does not include age. It outperforms both FIB-4 and APRI.

Fatty Liver Index is one of the best models to predict liver fat content.

A crude proxy for peripheral T4-to-T3 conversion (deiodinase activity).

Free T3 to reverse T3 ratio reflects the balance between thyroid hormone activation (T4→T3) and inactivation (T4→rT3).

HOMA1-IR has a poor correlation (r = -0.60) with the gold standard - Glucose clamp index of insulin sensitivity.

Liver stiffness score is currently one of the best models to predict liver fibrosis. Outperforms FIB-4, APRI and HSI. Trained on NHANES dataset.

Estimated pituitary TSH sensitivity to free T4, maintaining stability at extreme hormone values.

Estimated pituitary TSH sensitivity to free T3. This is a newer, less validated index, but may add value in some contexts.

QUICKI correlates well (r = 0.78) with the gold standard - Glucose clamp index of insulin sensitivity

R-Factor is used for distinguishing acute liver injury (Hepatocellular from Cholestatic). Often used when drug induced liver injury (DILI) is suspected.

Risk-weighted ApoB is currently the best single marker of atherogenic risk that accounts for the differing cardiovascular risk contributions of LDL, TRL/remnant, and Lp(a) particles.

Estimated maximum peripheral T4 to T3 conversion. Unlike simple FT3/FT4 ratios, it accounts for nonlinear enzyme kinetics.

Estimated maximum thyroid hormone production capacity of the gland under TSH stimulation. Not sensitive to isolated secondary (pituitary) disorders.

Triglyceride-to-HDL ratio is a surrogate marker of insulin resistance, NAFLD and atherogenic dyslipidemia.

Quantifies pituitary TSH sensitivity to free T4. Commonly used, but less reliable at extreme hormone values.

Ratio of total testosterone to estradiol. Used as a rough proxy for aromatase activity / relative estrogen dominance in men.

Triglyceride-glucose index is an inexpensive non-insulin surrogate marker of insulin resistance.

Triglyceride-Glucose index multiplied by BMI is one of the best models to predict NAFLD.

Urine Albumin-to-Creatinine Ratio from a spot urine sample. Used to detect and stage albuminuria, an early marker of kidney damage and a strong predictor of cardiovascular and renal outcomes.

Urine Protein-to-Creatinine Ratio from a spot urine sample. Used to detect and stage proteinuria; captures albumin and other proteins, complementing uACR when non-albumin proteinuria is suspected.