DHEAS in Serum

Most abundant adrenal androgen and a stable marker of adrenal androgen output (sulfated, long half-life, minimal diurnal variation). A sex-hormone precursor that declines steadily with age.
Also known as:
DHEA Sulfate
S-DHEAS
.

DHEAS ranges for

Interpret your result
"Normal" lab range for DHEAS is between 5.7 and 13.4 µmol/L for males:
5.7
13.4
According to OptimalDX, DHEAS should be between 9.5 and 18.73 µmol/L for males:
9.5
18.73
Optimal range
Optimal range for DHEAS appears to be between 9.5 and 18 µmol/L for males:
0
4
9.5
18
19
22
Why this optimal range?
Preliminary range is based on functional health organizations including but not limited to those listed above.

What a low value may mean:

Common reasons for low DHEAS:

  • Low DHEA-S most often reflects aging ("adrenopause") — levels peak in the mid-20s and fall steadily thereafter.

    Other causes: adrenal insufficiency (Addison's), hypopituitarism or central hypoadrenalism, corticosteroid use, and chronic stress, illness, or metabolic disease (type 2 diabetes, insulin-resistant obesity).

    ,

What a high value may mean:

Common reasons for high DHEAS:

  • In women, PCOS is the most common cause of high DHEA-S, often alongside hirsutism and insulin resistance.

    Other causes: congenital adrenal hyperplasia, adrenal tumors or carcinoma (markedly high or rapidly rising levels), Cushing's syndrome, and DHEA supplementation.

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Zsolt Szabo
Zsolt Szabo
Precision Health Consultant for Longevity Clinics

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I am particularly interested in research on biomarkers associated with all-cause mortality and on defining optimal reference ranges.