D/T Bilirubin Ratio

The D/T ratio is used to differentiate between different types of jaundice and liver injury patterns.
Also known as:
DT-Bili
.
Enter values
 
Value
Unit
Bilirubin (Total)
Bilirubin (Direct)

D/T Bilirubin Ratio ranges

Risk Scale
Optimal differential diagnosis cutoffs for the D/T Bilirubin Ratio appear to be:
0
Pre-hepatic
0.2
Hepatocellular
0.5
Cholestatic
1
  • < 0.2 - Pre-hepatic
  • 0.2 - 0.5 - Hepatocellular
  • > 0.5 - Cholestatic

The D/T ratio is used to differentiate between different types of jaundice and liver injury patterns.

Bilirubin breakdown:
Unconjugated:
000%
Conjugated (direct):
000%
Total:
000%

D/T Bilirubin Ratio interpretation

What a pre-hepatic result may mean:

Pre-hepatic pattern - mostly unconjugated bilirubin. The liver is conjugating normally; excess comes from over-production.

Pre-hepatic pattern is most commonly seen in hemolytic processes (e.g., autoimmune hemolytic anemia, transfusion reactions) and benign unconjugated syndromes (Gilbert's syndrome).

What a hepatocellular result may mean:

Hepatocellular injury pattern - both conjugation and canalicular export partly impaired.

Hepatocellular pattern is mostly seen in acute viral hepatitis or toxin/alcohol-related hepatocellular damage.

What a cholestatic result may mean:

Cholestatic / obstructive pattern - predominantly conjugated bilirubin. Bilirubin is conjugated but can’t reach the gut.

Cholestatic pattern is most commonly seen in extra-hepatic biliary obstruction, like in choledocholithiasis; malignancy or less frequently intra-hepatic cholestasis.

Images

Bilirubin Values in Normal and Various Pathological Conditions

Bilirubin Values in Normal and Various Pathological Conditions

Bilirubin Values Various Pathological Conditions

Bilirubin Values Various Pathological Conditions

Individual Biomarkers

See how each biomarker is interpreted on its own.

Bilirubin (Total): 000 mg/dL

Heme-catabolism end-product processed by the liver and excreted in bile, reflecting hemolysis and hepatic clearance.
0.25
0.6
1.1
1.5
4

Bilirubin (Direct): 000 mg/dL

Direct Bilirubin
0
0.15
0.3
2

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