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Bilirubin (Total) in Serum

Heme-catabolism end-product processed by the liver and excreted in bile, reflecting hemolysis and hepatic clearance.
Also known as:
Total BilirubinS-tBILtBILTotal Bili.

Bilirubin (Total) ranges

Interpret your result
"Normal" lab range for Bilirubin (Total) is between 0.2 and 1.1 mg/dL:
0.2
1.1
According to Peter Attia, Bilirubin (Total) should be below 1.2 mg/dL:
1.2
According to OptimalDx, Bilirubin (Total) should be between 0.5 and 0.9 mg/dL:
0.5
0.9
Lowest all cause mortality was associated with Bilirubin (Total) between 0.55 and 1.05 mg/dL:
0.35
0.55
1.05
1.55
2.95
Optimal range
Optimal range for Bilirubin (Total) appears to be between 0.6 and 1.1 mg/dL:
0.25
0.6
1.1
1.5
4
Why this optimal range?
Preliminary range is based on functional health organizations including but not limited to those listed above.

What a low value may mean:

Common reasons for low Bilirubin (Total):

  • Low total bilirubin is associated with systemic inflammation, oxidative stress, stroke, increased carotid intima-media thickness, arterial stiffness, diabetic peripheral neuropathy, metabolic syndrome, and Chronic Kidney Disease.

    Drugs that can decrease bilirubin levels: smoking, caffeine, barbiturates, penicillin, and large doses of salicylates.

    ,

What a high value may mean:

Common reasons for high Bilirubin (Total):

  • High total bilirubin is associated with liver dysfunction, hepatitis, Gilbert’s Syndrome, Strenuous Exercise, Gallstones and Gallbladder Disease, Pancreatitis, Appendicitis, obstruction of extrahepatic ducts, RBC hemolysis.

    ,

Images:

Total bilirubin was associated with all cause mortality

Total bilirubin was associated with all cause mortality

44,508 participants
Dataset: NHANES
Prospective cohort study

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Zsolt Szabo
Zsolt Szabo
Precision Health Consultant for Longevity Clinics

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I am particularly interested in research on biomarkers associated with all-cause mortality and on defining optimal reference ranges.