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GGT in Serum

Serum Gamma-glutamyl transferase usually originates from hepatocytes and cholangiocytes (plus pancreas).
Roche method sheet
Also known as:
Gamma-glutamyl transferaseS-GGTGMT.

GGT ranges for

Interpret your result
Normal reference range: 11–62 IU/L for males
11
62
According to OptimalDX, GGT should be between 10 and 17 IU/L:
10
17
Optimal range
Optimal range for GGT appears to be between 8 and 17 IU/L for males:
0
8
17
60
100
Why this optimal range?
Preliminary range is based on functional health organizations including but not limited to those listed above.

What a low value may mean:

Common reasons for low GGT:

  • Low GGT levels are usually not concerning. However, they may indicate Acute intrahepatic cholestasis, Hypothyroidism, magnesium deficiency or vitamin B6 deficiency, bone disease (low bone mass density).

    Drugs that can cause low GGT: Fibrate Drugs (Clofibrate, Fenofibrate), Estrogen-Containing Medications,milk thistle, antioxidants.

    ,

What a high value may mean:

Common reasons for high GGT:

  • Major serum GGT contributors: Liver (both hepatocytes and cholestasis), gallbladder, pancreas and kidneys. Also increased in insulin resistance, toxin exposure, oxidative stress and increased antioxidants (glutathione) need etc.

    Drugs that can increase GGT: Alcohol, anti-seizure medications and more.

    ,

Possible consequences from high GGT:

  • Above 16.5 IU/L was associated with metabolic syndrome
  • Above 20.5 IU/L was associated with impaired glucose tolerance
  • Above 18 IU/L was associated with insulin resistance, prehypertension, and cancer,,

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