ApoA1 in Serum

ApoA1 more closely reflects the amount of HDL particles present than HDL-C, which measures cholesterol cargo. It is also a negative acute-phase reactant (inflammation lowers it).

Paired with ApoB as the ApoB/ApoA1 ratio, it weighs atherogenic particle burden against protective HDL particles, often tracking cardiovascular risk better than either marker alone.

Also known as:

Apolipoprotein A-1

S-ApoA1

ApoA1 ranges for

Interpret your result

"Normal" lab range for ApoA1 is between 1.04 and 2.02 g/L for males:

1.04

2.02

According to ESC/EAS 2011 Guideline, ApoA1 should be above 1.2 g/L for males:

1.2

According to OptimalDX, ApoA1 should be between 1.5 and 2.1 g/L:

1.5

2.1

According to Faaborg-Andersen et al. (2023), ApoA1 should be between 1.31 and 1.73 g/L for males:

1.31

1.73

Optimal range

Optimal range for ApoA1 appears to be between 1.3 and 1.8 g/L for males:

0.5

1.2

1.3

1.8

2.1

Why this optimal range?

Preliminary range is based on functional health organizations including but not limited to those listed above.

For atherogenic risk, ApoA1 is best interpreted in context of ApoB, especially as the ApoB/ApoA1 ratio.

Modern lipid guidelines generally do not specify optimal ApoA1 treatment targets; they focus on LDL-C, non-HDL-C, ApoB, Lp(a), and overall ASCVD risk.

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Images:

ApoA1 showed a U-shaped association with all-cause mortality in men

402,783 participants

UK Biobank participants without known coronary artery disease

Prospective cohort study

Faaborg-Andersen et al. (2023)

ApoA1 showed a U-shaped association with all-cause mortality in women

402,783 participants

UK Biobank participants without known coronary artery disease

Prospective cohort study

Faaborg-Andersen et al. (2023)

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