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ALT in Serum

Highly liver-specific transaminase, but with minor contributions from skeletal and cardiac muscle, pancreas, and gut.
Also known as:
Alanine AminotransferaseS-ALTSGPT.

ALT ranges for

Interpret your result
"Normal" lab range for ALT is between 12 and 48 IU/L for males:
12
48
According to Peter Attia, ALT should be below 25 IU/L for males:
25
According to OptimalDX, ALT should be between 10 and 26 IU/L:
10
26
Optimal range
Optimal range for ALT appears to be between 10 and 26 IU/L:
0
7
10
26
30
80
Why this optimal range?
Preliminary range is based on functional health organizations including but not limited to those listed above.

What a low value may mean:

Common reasons for low ALT:

  • Low ALT levels are associated with low muscle mass (e.g., elderly, frail), Vitamin B6 Deficiency, Chronic Kidney Disease, CVD and cancer mortality in the elderly.

    ,

What a high value may mean:

Common reasons for high ALT:

  • ALT is highly specific to liver injury (Fatty liver, Viral hepatitis, Autoimmune hepatitis, Liver cancer, Alcohol liver damage, Mononucleosis, Hemochromatosis).

    Muscle damage – strenuous exercise, trauma, myocardial infarction, congestive heart failure.

    Gallstones; Biliary disease; pancreatitis; both obesity and anorexia; rapid weight change; celiac disease; hemolysis.

    Many toxins and drugs can increase ALT, but most notable are: Paracetamol, NSAIDs, statins, phenytoin, allopurinol, and antibiotics, especially amoxicillin.

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Zsolt Szabo
Zsolt Szabo
Precision Health Consultant for Longevity Clinics

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I am particularly interested in research on biomarkers associated with all-cause mortality and on defining optimal reference ranges.