tPSA in Serum

Prostate-derived serine protease measured as free plus protein-bound PSA. Influenced by age, prostate volume, prostatitis, recent ejaculation/instrumentation, and 5-alpha reductase inhibitors.
Also known as:
Total Prostate-Specific Antigen
S-tPSA
PSA
Total PSA
.
Do not confuse with free PSA.

tPSA ranges for

Interpret your result
"Normal" lab range for tPSA is between 0 and 4 ng/mL for males:
4
According to OptimalDX, tPSA should be between 0 and 2 ng/mL for males:
2
According to NAACCR SSDI, tPSA should be between 0 and 2.6 ng/mL for males:
2.6
According to Peter Attia, tPSA should be below 0.45 ng/mL for males:
0.45
Optimal range
Optimal range for tPSA appears to be below 2 ng/mL for males:
0
2
4
10
Why this optimal range?
Preliminary range is based on functional health organizations including but not limited to those listed above.

What a high value may mean:

Common reasons for high tPSA:

  • High PSA most often reflects increased prostate activity or disruption of the prostate barrier: benign prostatic hyperplasia, prostatitis, urinary infection, prostate cancer, urinary retention, or recent urologic instrumentation, biopsy, TURP, or trauma.

    Transient factors: recent ejaculation, vigorous cycling or exercise, and recent prostate manipulation can temporarily raise PSA; a newly elevated result is commonly repeated after the trigger resolves.

    Interpretation modifiers: PSA rises with age and prostate volume, and is best interpreted with trend, free PSA or PSA density when relevant, symptoms, risk factors, and exam findings.

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Zsolt Szabo
Precision Health Consultant for Longevity Clinics

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