hsCRP in Serum

Sensitive acute-phase marker made mainly by the liver in response to IL-6. Best interpreted when stable because infection, trauma, strenuous exercise, and estrogen therapy can raise it.

hsCRP is just a more sensitive version of the standard CRP test (they measure the same analyte). The standard CRP test is less sensitive and is usually only used to detect acute inflammation, while hsCRP can detect lower levels of inflammation and is often used to assess cardiovascular risk.

Also known as:
High-Sensitivity C-Reactive Protein
S-hsCRP
.

hsCRP ranges for

Interpret your result
"Normal" lab range for hsCRP is between 0 and 3 mg/L:
3
According to Peter Attia, hsCRP should be below 1 mg/L:
1
According to OptimalDX, hsCRP should be below 0.55 mg/L for males:
0.55
Optimal range
Optimal range for hsCRP appears to be below 0.6 mg/L:
0
0.6
3
10
Why this optimal range?
Preliminary range is based on functional health organizations including but not limited to those listed above.

What a high value may mean:

Common reasons for high hsCRP:

  • High hsCRP most often reflects active inflammation: recent infection, injury, surgery, autoimmune or inflammatory disease, periodontal disease, or other tissue injury. Repeat when clinically stable; persistent values above 10 mg/L warrant non-cardiovascular evaluation.

    Chronic low-grade elevation is commonly linked with adiposity and cardiometabolic risk: insulin resistance, metabolic syndrome, NAFLD, sleep apnea, smoking, sedentary behavior, and estrogen/progestin therapy.

    ,

Images:

CRP increases 3-5 fold during aging

CRP increases 3-5 fold during aging

High CRP was associated with substantial rise in mortality

High CRP was associated with substantial rise in mortality

CRP increases during aging

CRP increases during aging

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Zsolt Szabo
Zsolt Szabo
Precision Health Consultant for Longevity Clinics

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I am particularly interested in research on biomarkers associated with all-cause mortality and on defining optimal reference ranges.