Creatinine in Serum

Waste product of muscle creatine metabolism filtered by the kidneys. Strongly influenced by muscle mass, dietary meat intake, creatinine supplementation, and recent strenuous exercise.
Also known as:
S-creatinine
S-KREA
.

Creatinine ranges for

Interpret your result
"Normal" lab range for Creatinine is between 59 and 104 µmol/L for males:
59
104
According to OptimalDX, Creatinine should be between 70 and 97 µmol/L:
70
97
Optimal range
Optimal range for Creatinine appears to be between 65 and 97 µmol/L for males:
0
53
65
97
106
200
Why this optimal range?
Preliminary range is based on functional health organizations including but not limited to those listed above.

What a low value may mean:

Common reasons for low Creatinine:

  • Low creatinine usually reflects low muscle mass — sarcopenia, frailty, disuse atrophy.

    Other causes: low protein intake or malnutrition, pregnancy (increased GFR and plasma volume expansion), and advanced liver disease (impaired hepatic creatine synthesis).

What a high value may mean:

Common reasons for high Creatinine:

  • High creatinine usually reflects impaired kidney clearance — acute or chronic kidney disease, diabetic nephropathy, urinary obstruction, or reduced renal perfusion (dehydration, shock, congestive heart failure, renal artery atherosclerosis).

    Increased production: rhabdomyolysis or muscle trauma, intense exercise (i.e. long distance running, bodybuilding), myocardial infarction, acromegaly, high cooked red meat intake and creatine supplementation.

    ,

Images:

Creatinine increases during aging

Creatinine increases during aging

Creatinine increases with muscle mass

Creatinine increases with muscle mass

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Zsolt Szabo
Zsolt Szabo
Precision Health Consultant for Longevity Clinics, Biohacker, and Software Engineer

Please send me relevant research and feedback.

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I am particularly interested in research on biomarkers associated with all-cause mortality and on defining optimal reference ranges.