R-Factor

R-Factor is used for distinguishing acute liver injury (Hepatocellular from Cholestatic). Often used when drug induced liver injury (DILI) is suspected.
Also known as:
R-value
.
Enter values
 
Value
Unit
ALT
ALP

R-Factor ranges

According to Chalasani et al. (2021):
2
5
Risk Scale
Optimal differential diagnosis cutoffs for the R-Factor appear to be:
0
Cholestatic
2
Mixed
5
Hepatocellular
15
  • < 2 - Cholestatic
  • 2 - 5 - Mixed
  • > 5 - Hepatocellular

R-Factor is used for distinguishing acute liver injury (Hepatocellular from Cholestatic). Often used when drug induced liver injury (DILI) is suspected.

R-Factor interpretation

What a cholestatic result may mean:

Cholestasis is seen in: Gallstones; Malignancy (pancreatic, cholangiocarcinoma); Primary Biliary Cholangitis (PBC); Primary Sclerosing Cholangitis (PSC), often associated with IBD;

Drugs associated with cholestasis: Amoxicillin-clavulanate; macrolides (erythromycin); trimethoprim-sulfamethoxazole; anabolic steroids; combined oral contraceptives; chlorpromazine.

What a mixed result may mean:

Mixed pattern / inconclusive.

If the presentation is not acute, this pattern is most often seen with fatty liver (NAFLD or alcohol-related).

What a hepatocellular result may mean:

A hepatocellular pattern is seen in: Viral Hepatitis or other viral infections; Autoimmune hepatitis; ischemic “shock” liver; Wilson's disease, hemochromatosis, alpha-1 antitrypsin deficiency; Toxin exposure; Budd-Chiari syndrome

Drugs associated with hepatocellular pattern: Acetaminophen (paracetamol); statins; certain antibiotics (e.g., isoniazid, nitrofurantoin); antiepileptics (e.g., valproate, phenytoin); NSAIDs (e.g., diclofenac); methotrexate; amiodarone; herbal/dietary supplements.

Individual Biomarkers

See how each biomarker is interpreted on its own.

ALT: 000 IU/L

Highly liver-specific transaminase, but with minor contributions from skeletal and cardiac muscle, pancreas, and gut.
0
7
10
26
30
80

ALP: 000 IU/L

Alkaline phosphatase is primarily released from the bile ducts and bone. Minor sources include the intestinal mucosa, kidneys, and placental tissue (during pregnancy).
20
40
50
100
130
180

Get the Full Picture of Your Liver Health

Comprehensive liver function test interpretation tool that automatically calculates key liver health indexes and provides recommendations based on official clinical guidelines.

View Full Analysis

100% free and private. Enter only the values you have.

About the site author

My personal mission is to extend human lifespan by collectively adding 1 million years to people's lives.

That’s why I made this site 100% free, no sign-up, no email. Just instant results.

Zsolt Szabo
Zsolt Szabo
Precision Health Consultant for Longevity Clinics

How would you improve this tool ?

Any feedback is welcome at .