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Uric acid in Serum

End product of purine metabolism and a major plasma antioxidant, mostly cleared by kidneys. Influenced by renal excretion, purine, fructose, and alcohol intake.
Roche Method Sheet
Also known as:
S-uric-acidURICSerum urateS-UA.

Uric acid ranges for

Interpret your result
"Normal" lab range for Uric acid is between 3.4 and 7 mg/dL for males:
3.4
7
According to Peter Attia, Uric acid should be below 5 mg/dL:
5
According to OptimalDX, Uric acid should be between 3.5 and 5.4 mg/dL for males:
3.5
5.4
According to David Perlmutter, Uric acid should be below 5.5 mg/dL:
5.5
According to Kuwabara et al. 2020, Uric acid should be below 5 mg/dL for males:
5
Optimal range
Optimal range for Uric acid appears to be between 3.5 and 5.4 mg/dL for males:
0
3.5
5.4
7
12
Why this optimal range?
Preliminary range is based on functional health organizations including but not limited to those listed above.

What a low value may mean:

Common reasons for low Uric acid:

  • Medication or treatment effect: xanthine oxidase inhibitors, uricosuric drugs, high-dose salicylates, losartan, fenofibrate, and high-dose vitamin C can lower serum urate.

    Increased renal urate loss: renal hypouricemia, Fanconi syndrome, SIADH, Wilson disease, diabetes with uricosuria, and proximal tubular drug toxicity.

    Reduced production or intake: severe liver disease, xanthinuria, molybdenum cofactor disorders, undernutrition, and very low-purine intake.

    ,,,

What a high value may mean:

Common reasons for high Uric acid:

  • Reduced excretion: chronic kidney disease, dehydration or hypovolemia, metabolic acidosis or ketosis, insulin resistance, thyroid or parathyroid disease, and drugs such as diuretics, niacin, low-dose aspirin, pyrazinamide, ethambutol, and cyclosporine.

    Increased production: high-purine foods, alcohol, fructose or sugary drinks, rapid weight loss or fasting, intense exercise, high cell turnover, tumor lysis, hemolysis, rhabdomyolysis, and psoriasis.

    Common complications: persistent hyperuricemia raises the likelihood of gout and uric acid kidney stones; many people remain asymptomatic.

    ,,,,

Possible consequences from high Uric acid:

  • Hypertension, diabetes, dyslipidemia, chronic kidney disease,
  • Kidney stones, Gout (deposits of uric acid crystals in joints),

How to lower Uric acid:

  • Reducing fructose intake
    Sugar (sucrose), fruit juice, honey, agave, maple syrup, coconut sugar, high-fructose corn syrup etc. are all high in fructose. In fact, sugar is 1:1 fructose to glucose, while "healthy sugar alternatives" like honey, juices, agave are higher in fructose than glucose.

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Zsolt Szabo
Zsolt Szabo
Precision Health Consultant for Longevity Clinics

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I am particularly interested in research on biomarkers associated with all-cause mortality and on defining optimal reference ranges.