C-peptide/insulin

C-peptide to insulin molar ratio is helpful in detecting exogenous insulin use, impaired hepatic insulin clearance and impaired C-peptide clearance by the kidneys.
Also known as:
C-peptide-insulin-ratio
.
Enter values
 
Value
Unit
C-peptide
Insulin

C-peptide/insulin ranges

According to Grandt et al. (2023), C-peptide/insulin should be above 8:
8
According to Kron et al. (2020), C-peptide/insulin should be above 13:
11
13
Risk Scale
Optimal range for C-peptide/insulin appears to be between 11 and 17:
0
4
11
17
18
This isn't medical advice. Consult your healthcare provider.

C-peptide to insulin molar ratio is helpful in detecting exogenous insulin use, impaired hepatic insulin clearance and impaired C-peptide clearance by the kidneys.

Pancreatic β-cells secrete insulin and C-peptide into the portal vein in a 1 : 1 molar ratio.

More than half of the insulin is cleared on first pass by the liver, whereas C-peptide bypasses the liver and is removed more slowly by the kidneys (half-lives: insulin ≈ 5 min, C-peptide ≈ 30 min).

C-peptide/insulin interpretation

For low

Decreased c-peptide to insulin ratio is seen in states of reduced hepatic insulin extraction, (e.g., Liver fibrosis).

Low ratio is seen in exogenous insulin intake and in rare insulin-receptor/mutant-insulin syndromes.

For high

High c-peptide to insulin ratio is most often seen when renal clearance of C-peptide is reduced (e.g., chronic kidney disease).

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