TT/E2
TT/E2 ranges for
Ratio of total testosterone to estradiol. Used as a rough proxy for aromatase activity / relative estrogen dominance in men.
Not a molar ratio - computed as TT (ng/dL) / E2 (pg/mL), since this ratio is most commonly reported in the research.TT/E2 interpretation
For low
In men, low TT:E2 is seen in obesity/metabolic syndrome, worse sexual function, more inflammatory and unstable atherosclerotic plaque and worse CVD outcomes.
For high
In men, high TT:E2 is seen in relative estrogen-deficiency states (classically with aromatase inhibition or rare aromatase deficiency), and while sometimes discussed as “favorable” for spermatogenesis in infertility contexts, extremes may trade off against outcomes like bone density and possibly cerebrovascular risk.
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