Estradiol in Serum

Primary estrogen in both sexes, produced mainly by ovaries in females and via peripheral aromatization of testosterone in males.
Also known as:
S-estradiol
S-E2
.

Estradiol ranges for

Interpret your result
"Normal" lab range for Estradiol is between 11.3 and 43.3 pg/mL for males:
11.3
43.3
According to Peter Attia, Estradiol should be between 25 and 45 pg/mL for males:
25
45
According to OptimalDX, Estradiol should be between 24 and 39 pg/mL for males:
24
39
Optimal range
Optimal range for Estradiol appears to be between 24 and 44 pg/mL for males:
0
12
24
44
50
150
Why this optimal range?
Preliminary range is based on functional health organizations including but not limited to those listed above.
Your interpretation
For low
For high

Common reasons for low Estradiol:

  • In men: Low estradiol is seen with low testosterone / reduced aromatization, aromatase inhibitor therapy, and androgen deprivation therapy. It may contribute to reduced libido, vasomotor symptoms, and bone loss.

    In women: Low estradiol is seen with menopause, primary ovarian insufficiency, functional hypothalamic amenorrhea / low energy availability, hypopituitarism, and aromatase inhibitor therapy. In premenopausal women, results should be interpreted in the context of cycle phase.

    ,

Images:

Estradiol declines with age in women

Estradiol declines with age in women

About the site author

My personal mission is to extend human lifespan by collectively adding 1 million years to people's lives.

That’s why I made this site 100% free—no sign-up, no email. Just instant results.

Zsolt Szabo
Zsolt Szabo
Precision Health Consultant for Longevity Clinics, Biohacker, and Software Engineer

Please send me relevant research and feedback.

Any feedback is welcome at .
I am particularly interested in research on biomarkers associated with all-cause mortality and on defining optimal reference ranges.