cB12
cB12 ranges
- < -2.5 - Symptomatic B12 deficiency
- -2.5 - -1.5 - Possible deficiency symptoms
- -1.5 - -0.5 - Subclinical B12 deficiency
- green - Adequate
- > 1.5 - Elevated
Combined indicator of B12 status estimates functional vitamin B12 status from two to four B12-related markers, with lower precision when fewer markers are available.
cB12 interpretation
What a low value may mean:
Low B12 most often reflects inadequate intake (vegan or vegetarian diets, chronic alcohol use) or malabsorption.
Malabsorption causes include pernicious anemia (autoimmune loss of intrinsic factor), celiac disease, Crohn’s disease, atrophic gastritis, low stomach acid, prior gastric or ileal surgery, inflammatory bowel disease, and H. pylori or small intestinal bacterial overgrowth.
Common drug causes: long-term metformin, proton pump inhibitors, and H2 blockers.
What a high value may mean:
Elevated B12 status after supplementation is not concerning and usually desirable in athletes (for HGB production).
Unexplained persistent high B12: possible causes include liver disease, kidney disease, myeloid/hematologic disease, autoimmune disease, leukemia, and solid tumors.
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