Elevated prolactin is commonly caused by prolactinoma, medications (especially antipsychotics, metoclopramide, antidepressants, opioids, methyldopa, and some calcium-channel blockers), hypothyroidism, and pregnancy/lactation.
Prolactin can also rise transiently with stress, sleep, exercise, sex, nipple stimulation, and chest wall stimulation or injury. Other causes include pituitary stalk lesions, chronic kidney disease, and liver disease.
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